怀孕期间的叶酸补充剂和流产风险
1National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30341-3724, USA.
Lancet (London, England)
|September 21, 2001
概括
在怀孕前和早期服用400微克叶酸不会影响流产风险. 这项研究没有发现任何证据表明叶酸补充剂会影响第一次怀孕中流产的发生.
科学领域:
- 产科和妇科 产科和妇科
- 生殖健康 生殖健康
- 营养科学 营养科学
背景情况:
- 在怀孕前和怀孕期间补充叶酸 (400微克) 已知可以降低神经管缺陷 (NTD) 的风险.
- 叶酸对其他妊娠结果 (如流产) 的影响仍然不太清楚.
研究的目的:
- 调查叶酸补充剂与流产风险之间的关联.
- 为了确定在怀孕前和早期服用400微克叶酸是否会影响流产的发生.
主要方法:
- 在中国进行了一项队列研究,该研究涉及在叶酸运动中注册的首次怀孕妇女.
- 分析了在怀孕前和怀孕初期服用或未服用400微克叶酸补充剂的妇女的怀孕结果.
主要成果:
- 在研究人群中,整体流产率为9.1%.
- 服用叶酸 (9.0%) 和不服用叶酸 (9.3%) 的妇女的流产率相似 (风险比0.97).
- 诊断时的妊娠年龄和流产在补充和不补充组之间是可比的.
结论:
- 在怀孕初期和怀孕前每天摄入400微克叶酸并没有对该人群中流产风险产生影响.
- 这些发现表明,以这种剂量补充叶酸并不会增加或减少流产的可能性.
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