在高心率诱导的心肌病变症中, mitra 吐的发病因子
1Department of Cardiovascular and Thoracic Surgery, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Circulation
|September 25, 2001
概括
功能性额外外 (MR) 在心跳动脉诱发性心肌病 (TIC) 源于由于扩大了额外. 环状减小手术可以有效地治疗扩张性心肌病的这种情况.
科学领域:
- 心血管研究研究心血管研究
- 心脏机械学 心脏机械学
- 医疗成像医学成像
背景情况:
- 扩张性心肌病症经常涉及功能性 mitrale 吐 (MR).
- 驱动功能性MR的精确机制仍在调查中.
- 这项研究研究了心动脉冲动心肌病 (TIC) 模型中的膜和心室几何学.
研究的目的:
- 为了阐明与TIC中MR相关的三维几何变化,在中枢和左心室 (LV) 中.
- 了解在这个模型中导致功能性MR的特定扰动.
主要方法:
- 利用一种由快速心室节奏诱导的TIC的绵羊模型.
- 植入心肌标记器在LV,心肌环,以及用于3D运动跟踪的传单.
- 在TIC发育之前和之后,使用双平面视频光镜和跨食道心声扫描来评估中位管能力和LV尺寸.
主要成果:
- 信息通信技术显著增加了LV体积和球状性.
- 副回的严重程度大大增加 (级别为0.2至2.2).
- mitra annulus 的尺寸,特别是隔膜-侧面直径,显著增加,导致叶片边缘分离的增加和合的减少.
结论:
- 在TIC中,功能性MR主要是由由于显著的 mitra环状扩张而减少的叶片合合引起的.
- 这些发现支持了诸如环结合手术 (ring annuloplasty) 之类的友节环状缩小技术在扩张性心肌病中治疗功能性MR的有效性.
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