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功能性心肌缺血与脑死亡猪心肌功能障碍相关的证据
C Seguin1, Y Devaux, S Grosjean
1Laboratoire de Chirurgie Expérimentale, Faculté de Médecine de Nancy, Université Henri Poincaré, Nancy I, France.
Circulation
|September 25, 2001
概括
大脑死亡导致心肌功能障碍,原因是氧气供需不平衡,其证据是乳酸和腺的增加. Labetalol治疗减轻了这种功能障碍,保持了猪的有氧代谢.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 生理学 生理学 生理学
背景情况:
- 大脑死亡后的心脏功能障碍是公认的,但不太了解.
- 心肌缺血是一种被提议的机制,在脑死亡后导致心脏功能障碍.
研究的目的:
- 为了调查心肌氧供应和需求之间的不平衡是否会导致脑死亡猪的心脏功能障碍.
主要方法:
- 心脏微透析用于测量脑死亡猪和用labetalol治疗的猪的间歇性心肌乳酸和腺.
- 血液动力学参数包括心率,心脏输出和冠状动脉血流持续监测.
主要成果:
- 脑死亡的猪表现出心率,心脏输出和冠状动脉血流的增加,但冠状动脉血流的有限增加导致功能性心肌缺血.
- 心肌乳酸和腺氨酸度显著升高证实了脑死亡猪的缺血.
- 拉贝塔醇治疗稳定了心脏功能和有氧新陈代谢,心率和腺素的增加只有适度.
结论:
- 脑死亡诱导心肌功能障碍与间歇性腺和乳酸的增加有关.
- 这种功能障碍似乎源于心肌氧消耗和输送氧气之间的不平衡.
- 拉贝塔醇减弱了这些影响,这表明它在治疗脑死亡后心脏功能障碍方面的潜在作用.
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