在左心室辅助后正常化的透缩性质是由于室内几何结构的反向改造而产生的
A Barbone1, M C Oz, D Burkhoff
1Department of Surgery, Columbia University, New York, NY, USA.
Circulation
|September 25, 2001
概括
左心室 (LV) 辅助通过减少心脏大小,而不是通过改变组织硬性来使透析性质正常化. 这种几何重塑是 LV 辅助器件支持后改善腹功能的关键.
科学领域:
- 心血管生理学心血管生理学
- 生物医学工程 生物医学工程
- 心脏衰竭研究研究
背景情况:
- 扩张功能障碍是心力衰竭的标志.
- 左心室 (LV) 辅助设备用于支持失败的心脏.
- 在LV辅助后观察到透缩性质的正常化,但潜在的机制仍在争论中.
研究的目的:
- 测试该假设,LV辅助后改善的LV透气性质主要是由于腔室几何重塑.
- 要区分心肌物质性质的变化和几何变化.
主要方法:
- 从心脏移植接受者与扩张性心肌病 (DCM) 的心脏分析,并没有LV辅助.
- 测量被动的压力-体积曲线和室内尺寸.
- 计算中壁应力-拉伸关系和测量受动应力-拉伸关系在trabeculae.
- 肌细胞大小和原面积分量的组织学分析.
主要成果:
- LV协助正常化的被动压力-体积曲线.
- 房间尺寸在LV辅助后显著减少.
- 中壁应力拉伸和被动应力拉伸关系保持不变.
- 肌细胞大小和原含量没有改变.
结论:
- 在LV辅助后扩张性质的早期正常化归因于左心室的几何重塑.
- 心肌组织度的变化不能解释观察到的透静改善.
- 心室几何在心脏力学中起着至关重要的作用,而心脏缩小的尺寸并不能自动降低心脏壁应力.
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