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通过一种新的织心脏支装置进行被动制和反向改造

W F Konertz¹, J E Shapland, H Hotz

¹Department of Cardiovascular Surgery, Charité, Berlin, Germany. wolfgang.konertz@charite.de

|September 25, 2001

概括

一种新的心脏支持装置 (CSD) 显示出改善心脏功能和减少心力衰竭患者稳定的症状的希望. 这种植入式设备促进逆向重塑,提高心脏性能和生活质量.

科学领域:

心脏病学心脏病学
生物医学工程生物医学工程
再生医学是一种再生医学.

背景情况:

慢性心力衰竭涉及逐渐的心脏重塑和扩张,导致心肌功能障碍.
临床前研究表明,被动心脏约束装置可以促进逆向重塑和改善心脏功能.
这项研究调查了心脏抑制装置对稳定心力衰竭患者 (NYHA II-III类) 的潜在益处.

研究的目的:

评估在患有稳定慢性心力衰竭的患者中使用Acorn心脏支持装置 (CSD) 的安全性和可行性.
评估CSD植入对心脏功能,心室重塑和临床状态的影响.
确定设备对心力衰竭患者症状和生活质量的影响.

主要方法:

一项前性安全性和可行性研究,涉及27名心力衰竭患者 (NYHAII-III类).
木心脏支持装置 (CSD) 是一款织品聚设备,通过手术在心脏周围植入.
监测患者的临床状况,心声学参数 (射出分数,心室尺寸) 和 mitra 回.

主要成果:

所有27名患者都经历了手术并顺利康复.
在三个月内,56%的患者改善到NYHA I级,33%的患者改善到II级.
心声扫描显示左心室喷射分数有所改善 (22%至33%) 和末端透气尺寸减少 (74毫米至65毫米).
同心回明显减少,生活质量指数有所改善.

结论:

在短期到中期内,CSD植入似乎是安全的和可行的.
该设备显示出改善心力衰竭患者症状和改善心脏和功能表现的潜力.
全球随机试验正在进行中,以进一步验证这些发现.

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