在酵母细胞周期中的转录调节剂的序列调节
I Simon1, J Barnett, N Hannett
1Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
Cell
|September 27, 2001
概括
酵母细胞周期转录激活剂形成了一个循环网络,一个阶段的激活剂调节下一个阶段的激活剂. 这揭示了一个协调的系统,控制基因表达和细胞周期进展的细胞事件.
科学领域:
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
- 系统生物学 系统生物学
背景情况:
- 酵母细胞周期涉及复杂的基因表达程序.
- 转录激活剂在调节这些程序方面发挥着至关重要的作用.
- 了解调节网络是解读细胞循环控制的关键.
研究的目的:
- 阐明九种已知的酵母细胞周期转录激活剂的调节作用.
- 绘制控制酵母细胞循环的转录调节网络的地图.
- 了解这些激活器如何协调全球基因表达.
主要方法:
- 使用全基因组定位分析.
- 研究了细胞周期转录激活剂之间的调控相互作用.
主要成果:
- 确定了一种序列调节模式,其中一个细胞周期阶段的激活器调节下一个阶段的激活器.
- 证明这些激活剂形成了一个周期性调节网络.
- 显示了全球基因表达和特定阶段功能的协调调节.
结论:
- 九个转录激活剂形成一个连接的,循环的调节网络.
- 这个网络驱动着酵母细胞事件的连续循环.
- 提供了细胞周期转录调节网络的基础地图.
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