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年轻人的出生体重和血压:一个前双胞胎研究
1Faculty of Medicine, Center for Human Genetics, Hypertension and Cardiovascular Rehabilitation Unit, Faculty of Physical Education and Physiotherapy, Department of Sport and Movement Sciences, Katholieke Universiteit Leuven, Leuven, Belgium.
Circulation
|October 3, 2001
概括
产前编程会影响女性的成人血压,低出生体重与高血压有关. 母亲因素可能起到关键作用,特别是在出生体重低的双胞胎中.
科学领域:
- 生殖医学 生殖医学
- 发展生物学 发展生物学
- 心血管健康 心血管健康
背景情况:
- 子宫内环境是生命后期发展高血压的关键时期.
- 出生体重和成人血压之间的关系受遗传和环境因素的影响.
研究的目的:
- 用双胞胎研究方法估计遗传和环境原因对出生体重和成人血压相关性的贡献.
- 为了研究成人血压的产前编程.
主要方法:
- 预期收集418对双胞胎的出生体重.
- 在18-34岁的参与者中测量休息和24小时的门诊血压.
- 基于出生体重类别的双胞胎对血压对比的对智分析.
主要成果:
- 在女性中,较高的出生体重与较低的成年血压和腹压血压有关.
- 与高出生体重对相比,低出生体重 (<2500 g) 的双胞胎对表现出较高的缩血压.
- 在出生时体重较低的夫妇中观察到双胎内血压差异,这表明产前影响.
结论:
- 成年人血压的产前编程发生在女双胞胎身上.
- 影响到两个胎儿的母亲的影响,可能是出生体重与血压相关的基础.
- 当两个胎儿出生时体重低时,胎盘单位对血压的影响是显而易见的.
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