溶性粘附分子和冠心病的预测:一个前性研究和元分析
1BHF Cardiovascular Medicine Unit, National Heart and Lung Institute, Imperial College School of Medicine, Hammersmith Hospital, W12 0NN, London, UK.
Lancet (London, England)
|October 5, 2001
概括
溶性粘附分子,如ICAM-1,与冠心病 (CHD) 风险有关. 然而,它们提供了有限的额外预测价值,超出了已确定的CHD风险因素.
科学领域:
- 心血管研究的心血管研究.
- 发现生物标志物的发现.
- 流行病学 流行病学
背景情况:
- 以前的研究表明,可溶性粘附分子可以预测冠心病 (CHD) 风险.
- 需要进行更大规模的研究来验证这些发现.
研究的目的:
- 研究四种可溶性细胞粘附分子对冠心病 (CHD) 的预测价值.
- 评估这些分子是否能在传统风险因素之外增加预测信息.
主要方法:
- 血清中ICAM-1,VCAM-1,E-selectin和P-selectin的度在643名患有心脏病的男性和1278名对照人群中被测量.
- 对现有研究进行了元分析,以对发现进行上下文化.
- 根据年龄,城市,经典冠状动脉风险因素和社会经济地位进行了统计调整.
主要成果:
- 溶性粘附分子度相互相关,炎症标志物,以及一些心脏病风险因素.
- 细胞间粘附分子-1 (ICAM-1) 显示,CHD的初始几率比为1.68,在调整后降至1.11.
- 血管细胞粘附分子-1 (VCAM-1),E-selectin和P-selectin也显示出与心脏病的关联,但它们的预测能力在调整已确定的风险因素后减少.
结论:
- 这些可溶性粘附分子对冠心病 (CHD) 的预测价值有限.
- 测量这些粘附分子不太可能显著提高风险预测超出现有的既定风险因素.
更多相关视频
10:03Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
05:16Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
相关概念视频
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Acute Coronary Syndrome III: Diagnostic Studies
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
