淋巴管瘤在淋巴管和淋巴管瘤
J Moss1, R DeCastro, N J Patronas
1Room 6D05, Bldg 10, MSC 1590, National Institutes of Health, Bethesda, MD 20892-1590, USA. mossj@nhlbi.nih.gov
JAMA
|October 26, 2001
概括
患有淋巴管状瘤症 (LAM) 的女性患上脑膜瘤的患病率很高. 对于所有LAM患者,建议对大脑瘤进行查,在患有脑膜瘤的人群中应避免使用孕激素治疗.
科学领域:
- 神经学 神经学
- 肺部病理学 肺部病理学
- 在瘤学瘤学.
背景情况:
- 淋巴结核病 (Lymphangioleiomyomatosis,简称LAM) 是一种导致呼吸衰竭的囊性肺病,主要影响生育年龄的妇女.
- 荷尔蒙药物,包括孕激素,是由于其荷尔蒙影响而常见的LAM治疗方法.
- 脑膜瘤,带有孕激素受体的大脑瘤是令人担忧的,因为孕激素可能会刺激它们的生长.
研究的目的:
- 调查LAM诊断的女性中脑膜瘤的流行情况.
- 评估在LAM患者中进行脑膜瘤查的必要性,无论结核性硬化综合体 (TSC) 诊断如何.
主要方法:
- 分析了国家心脏,肺和血液研究所的查数据.
- 磁共振成像 (MRI) 和/或计算机断层扫描 (CT) 扫描用于脑病变查.
- 这项研究包括了250名零星LAM的妇女.
主要成果:
- 八名患有LAM的妇女 (6.4%) 呈现了MRI兼容的脑膜瘤病变.
- 在这八名患者中,有三名患者也被诊断为结核性硬化综合体 (TSC).
- 五名患有脑膜瘤的患者先前接受过孕激素治疗;两名患有多重脑膜瘤.
结论:
- 在患有LAM的女性中观察到高患病率的脑膜瘤.
- 建议对所有LAM患者进行常规的脑膜瘤查,无论TSC状态如何.
- 对于患有脑膜瘤的LAM患者,由于潜在的瘤生长刺激,应重新考虑孕激素治疗.
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