布拉迪基宁B2BKR受体多态性和左心室生长反应
Lancet (London, England)
|October 13, 2001
概括
血管素转化酶 (ACE) 和勃拉迪基宁2受体 (B2BKR) 的遗传变异在训练反应中影响左心室生长. 特定的ACE和B2BKR基因型与生理左心室适应的显著差异有关.
科学领域:
- 心血管生理学心血管生理学
- 人类遗传学 人类遗传学
- 运动科学 运动科学
背景情况:
- ангиотензин转化酶 (ACE) 的活性影响左心室 (LV) 的生长.
- 在ACE和布拉迪基宁2受体 (B2BKR) 基因中的遗传变异会影响酶活性和受体表达.
- 身体训练会诱导生理 LV 的生长.
研究的目的:
- 为了研究ACE和B2BKR基因多态和生理左心室生长在体育训练的反应之间的关联.
- 探索素在调解ACE相关效应对左心室重塑中的作用.
主要方法:
- 在109名男性军队新兵中,对ACE (D/I) 和B2BKR (-9/+9bp删除) 多态的基因定型.
- 在10周的体育训练计划中测量左心室生长.
- 统计分析以确定不同基因型组合的左心室生长趋势.
主要成果:
- 根据ACE和B2BKR基因型观察到左心室生长的显著差异.
- 具有ACE D/D和B2BKR +9/+9基因型的个体表现出大量的左心室生长 (15.7g).
- 具有ACE I/I和B2BKR -9/-9基因型的个体没有显著的左心室生长 (-1.37g).
结论:
- 基因因似乎在左心室生长中起着调节作用.
- 在ACE和B2BKR路径中的遗传变异显著影响左心室对运动的生理适应.
- 这些发现突显了心血管适应过程中氨酸-血管氨系统和氨酸-白氨酸系统之间的相互作用.
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