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系统性红血性狼中心血管疾病的危险因素

E Svenungsson¹, K Jensen-Urstad, M Heimbürger

¹Department of Rheumatology and Centre for Molecular Medicine, King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden. Elisabet.Svenungsson@medks.ki.se

|October 17, 2001

概括

患有心血管疾病 (CVD) 的全身性红斑狼 (SLE) 患者与没有心血管疾病的患者相比,表现出不同的危险因素,包括氧化LDL和脂质不良症. 识别这些因素可以帮助管理SLE患者的心血管疾病风险.

科学领域:

类风湿病学类风湿病学
心脏病学心脏病学
免疫学免疫学免疫学

背景情况:

心血管疾病 (CVD) 是系统性红斑狼 (SLE) 患者的一个重大问题.
了解SLE中心血管疾病的特定风险因素对于患者管理至关重要.

研究的目的:

确定SLE患者中传统和非传统心血管疾病风险因素的患病率,有或没有现有的心血管疾病.
将这些风险因素与一般人口对照组进行比较.

主要方法:

这是一项涉及三组患者的比较研究:带有心血管疾病的SLE患者 (SLE病例),没有心血管疾病的SLE患者 (SLE对照) 和人口对照.
通过超声波测量常见的动脉内心介质厚度 (IMT),作为动脉样硬化症的替代品.
血生物标志物的分析,包括氧化LDL (OxLDL),对OxLDL的自身抗体,甘油三,高密度LDL胆固醇,脂蛋白,α-1-抗素,狼抗凝剂和同类蛋白水平.

主要成果:

与SLE对照组和人口对照组相比,SLE病例显示IMT显著增加.
在SLE病例中,OxLDL,OxLDL的自身抗体,甘油三,脂蛋白 (a),α-1-抗素,狼抗凝剂和同型氨酸的水平较高.
与SLE对照组相比,SLE病例的骨质疏松症患病率更高,累计普雷尼索隆剂量更高.
在SLE病例和SLE对照之间,没有观察到疾病持续时间,吸烟,血压,BMI或糖尿病的显著差异.

结论:

一组独特的心血管疾病风险因素使SLE患者与心血管疾病患者以及普通人群区别开来.
这些已识别的风险因素可能被用来根据心血管疾病风险对SLE患者进行分层.
需要进行前性研究来证实这些发现,并优化SLE患者的心血管疾病风险管理.

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