在患有辅助途径的患者中,ibutilide的电生理效应
K A Glatter1, P C Dorostkar, Y Yang
1Cardiovascular Research Institute and Section of Adult and Pediatric Cardiac Electrophysiology, University of California, San Francisco, USA.
Circulation
|October 17, 2001
概括
伊布提利德有效地终止了沃尔夫-帕金森-怀特综合征患者的心房动 (AF),通过延长心房节和辅助通路 (AP) 的折射性. 这项研究包括第一例用于AP介导AF的ibutilide的儿科病例.
科学领域:
- 电子生理学 电子生理学
- 药理学 药理学是指药理学的学科.
- 心脏病学 心脏病学
背景情况:
- 在沃尔夫-帕金森-怀特综合征患者中,心房动 (AF) 构成危及生命的心室节律失常的风险.
- 辅助通路 (AP) 涉及到这些心律失常的病理生理学.
研究的目的:
- 为了前性地评估ibutilide对辅助通路 (AP) 患者心脏导电系统的影响.
- 评估伊布蒂利德在终止AP介导心房动 (AF) 的疗效.
主要方法:
- 第一部分:在电生理学研究期间,伊布利德给了22名AF患者,包括儿科患者.
- 第二部分:伊布提利德给了18名患者,以评估对AP和导电系统的影响.
- 测量包括心房节,AP和His-Purkinje系统的耐火期和阻断周期长度.
主要成果:
- 伊布提利德在95%的患者中终止了AF,并延长了最短的预激发R-R间隔.
- 伊布提利德显著延长了前期心房节有效耐火期 (ERP) 和前期AP ERP.
- 在61%的患者中,His-Purkinje系统的折射性增加;没有报告任何不良影响.
结论:
- 伊布提利德在终止AP介导的AF方面是有效的,包括在儿科人口中.
- 伊布提利德延长了心房节点,希斯-普尔金耶系统和辅助通路的折射性.
- 这表明布利在管理与沃尔夫-帕金森-怀特综合征相关的心律失常方面具有潜在的治疗作用.
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