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乌拉-DNA糖酶通过基质自催化作用

A R Dinner1, G M Blackburn, M Karplus

  • 1Central Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QH, UK.

Nature
|October 19, 2001
PubMed
概括

乌拉DNA糖酶 (UDG) 通过逐步解离机制催化DNA修复,而不是协调的关联机制. 基质酸盐,不仅仅是酶,显著降低了激活能量,揭示了一个意想不到的自催化贡献.

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