患有慢性心力衰竭相关的缓解症时,血红蛋白的循环水平升高:血红蛋白与合成代谢/转化因子之间的关系
N Nagaya1, M Uematsu, M Kojima
1Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan. nagayann@hsp.ncvc.go.jp
Circulation
|October 24, 2001
概括
患有慢性心力衰竭 (CHF) 的患者体内血胆固醇水平升高,而这些患者患有缓解症. 格林的这种增加可能是这些患者对代谢状态的补偿反应.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 代谢过程中的代谢.
背景情况:
- 格雷林是一种生长激素 (GH) 释放,影响能量平衡和脂肪.
- 慢性心力衰竭 (CHF) 经常与复杂的代谢综合征 - - 缓冲症有关.
- 格林在与慢性心血管疾病相关的缓解症的病理生理学中的作用需要研究.
研究的目的:
- 在慢性心力衰竭 (CHF) 患者中研究格林的作用和水平.
- 为了确定在CHF患者中格林和缓解症之间的关联.
- 为了探索格林和其他催化/合成因子之间的相关性,在CHF.
主要方法:
- 在74名心血管疾病患者和12名对照组中测量了血胆固醇水平.
- 慢性心血管功能障碍患者被分为卡切克性 (n=28) 和非卡切克性 (n=46) 组.
- 测量包括GH,TNF-alpha,北上腺素和血管新生素II.
主要成果:
- 血胆固醇在卡塞克性CHF患者中明显高于非卡塞克性CHF患者 (237+/-18对147+/-10 fmol/mL,P<0.001).
- 在卡塞克性CHF患者中观察到高GH,TNF-alpha,北上腺素和血管新生II.
- 血格林与GH和TNF-alpha正相关,与体重指数负相关.
结论:
- 血格林的升高与CHF患者的缓解症有关.
- 增加的格林素可能会作为一种补偿机制,在卡切克性CHF的代谢-代谢失衡.
- 格林在能量平衡中的作用在CHF缓解症的背景下需要进一步研究.
相关概念视频
Pathophysiology of Heart Failure
4.8K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.8K
Regulation of Food Intake
2.8K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
2.8K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
765
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
765
Heart Failure I: Introduction
1.7K
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
1.7K
Heart Failure II: Pathophysiology
1.9K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.9K
Heart Failure III: Clinical Manifestations
1.2K
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
1.2K


