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合理设计的diflunisal类似物与减少亲和力的人类血清白蛋白

H Mao1, P J Hajduk, R Craig

  • 1Pharmaceutical Discovery Division, Abbott Laboratories, Abbott Park, Illinois 60044, USA.

Journal of the American Chemical Society
|October 25, 2001
PubMed
概括

研究人员通过使用核磁共振 (NMR) 来引导基于结构的设计,减少了药物化合物与人血清白蛋白 (HSA) 的结合. 这种策略产生了具有较低HSA亲和力的化合物,同时保持了抗炎活性.

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