鉴定骨肌肉缩所需的乌比奎酸酶

S C Bodine1, E Latres, S Baumhueter

  • 1Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591-6707, USA.

Science (New York, N.Y.)
|October 27, 2001
PubMed
概括

研究人员确定了关键蛋白质,肌肉戒指1 (MuRF1) 和肌肉缩F-box (MAFbx),驱动骨肌肉缩. 缺乏这些蛋白质的小鼠对肌肉消耗表现出抵抗力,这表明它们是潜在的药物点.

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