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相关概念视频

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...

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Tissue specific loss of proliferative capacity of parthenogenetic cells in fetal mouse chimeras.

Roux's archives of developmental biology : the official organ of the EDBO·2017
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Distribution of androgenetic cells in fetal mouse chimeras.

Roux's archives of developmental biology : the official organ of the EDBO·2017
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Proliferation and differentiation of androgenetic cells in fetal mouse chimeras.

Roux's archives of developmental biology : the official organ of the EDBO·2017
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Epigenetic reprogramming of mouse germ cells toward totipotency.

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Germ line, stem cells, and epigenetic reprogramming.

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Germline recruitment in mice: a genetic program for epigenetic reprogramming.

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相关实验视频

Updated: Jul 5, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

通过表观遗传遗传对基因组功能进行重新编程.

M A Surani1

  • 1Wellcome CRC Institute of Cancer and Developmental Biology and Physiology Laboratory, University of Cambridge, UK. as10021@mole.bio.cam.ac.uk

Nature
|November 2, 2001
PubMed
概括

细胞分化源于选择性基因表达. 值得注意的是,细胞可以恢复全能性,使其能够重新编程用于治疗干细胞应用.

科学领域:

  • 细胞生物学 细胞生物学
  • 遗传学 是一个遗传学.
  • 发育生物学是发展生物学.

背景情况:

  • 所有细胞都具有相同的基因,但表现出不同的功能.
  • 选择性基因表达和抑制决定了细胞的身份和专业化.

研究的目的:

  • 探索基因组可塑性和可塑性背后的机制.
  • 了解分化细胞如何被重新编程.

主要方法:

  • 研究基因调节途径.
  • 分析表观遗传修饰.
  • 研究细胞重编程技术.

主要成果:

  • 确定了基因表达的关键调节者.
  • 证明了脱差和全能性的潜力.
  • 发现基因组可塑性的机制.

结论:

  • 细胞身份是塑性的,可以逆转.
  • 了解全能性对于干细胞疗法至关重要.
  • 进一步的研究将推动干细胞操纵用于医学.

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Analysis of Transgenerational Epigenetic Inheritance in C. elegans Using a Fluorescent Reporter and Chromatin Immunoprecipitation (ChIP)
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Analysis of Transgenerational Epigenetic Inheritance in C. elegans Using a Fluorescent Reporter and Chromatin Immunoprecipitation (ChIP)

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CRISPR Epigenome Editing in Human Cells using Plasmid DNA Transfection and mRNA Nucleofection Delivery
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CRISPR Epigenome Editing in Human Cells using Plasmid DNA Transfection and mRNA Nucleofection Delivery

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Last Updated: Jul 5, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

Analysis of Transgenerational Epigenetic Inheritance in C. elegans Using a Fluorescent Reporter and Chromatin Immunoprecipitation (ChIP)
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Analysis of Transgenerational Epigenetic Inheritance in C. elegans Using a Fluorescent Reporter and Chromatin Immunoprecipitation (ChIP)

Published on: May 5, 2023

CRISPR Epigenome Editing in Human Cells using Plasmid DNA Transfection and mRNA Nucleofection Delivery
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CRISPR Epigenome Editing in Human Cells using Plasmid DNA Transfection and mRNA Nucleofection Delivery

Published on: May 30, 2025