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相关概念视频

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Nucleosome Remodeling02:54

Nucleosome Remodeling

Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer is an enzyme that can...
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...

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相关实验视频

Updated: Jun 1, 2026

Targeted in Situ Mutagenesis of Histone Genes in Budding Yeast
08:48

Targeted in Situ Mutagenesis of Histone Genes in Budding Yeast

Published on: January 26, 2017

失去了Suv39h基因组甲基转移酶会损害哺乳动物的异染色素和基因组稳定性.

A H Peters1, D O'Carroll, H Scherthan

  • 1Research Institute of Molecular Pathology (IMP), Vienna Biocenter, Dr. Bohrgasse 7, A-1030, Vienna, Austria.

Cell
|November 10, 2001
PubMed
概括
此摘要是机器生成的。

通过Suv39h酶的素H3氨酸9甲基化 (H3-K9) 对周心异色素蛋白组织至关重要. 在小鼠中失去这些酶会导致基因组不稳定,发育问题和瘤风险增加.

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Unveiling Histone Proteoforms using 2D-TAU Gel Electrophoresis
07:20

Unveiling Histone Proteoforms using 2D-TAU Gel Electrophoresis

Published on: October 18, 2024

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Last Updated: Jun 1, 2026

Targeted in Situ Mutagenesis of Histone Genes in Budding Yeast
08:48

Targeted in Situ Mutagenesis of Histone Genes in Budding Yeast

Published on: January 26, 2017

Global Level Quantification of Histone Post-Translational Modifications in a 3D Cell Culture Model of Hepatic Tissue
08:12

Global Level Quantification of Histone Post-Translational Modifications in a 3D Cell Culture Model of Hepatic Tissue

Published on: May 5, 2022

Unveiling Histone Proteoforms using 2D-TAU Gel Electrophoresis
07:20

Unveiling Histone Proteoforms using 2D-TAU Gel Electrophoresis

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科学领域:

  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
  • 分子生物学分子生物学
  • 遗传学 是一个遗传学.

背景情况:

  • 基因组甲基化,特别是H3-K9甲基化,与调节色素结构和功能有关.
  • 周心异色素蛋白在基因组稳定性和染色体分离中起着至关重要的作用.

研究的目的:

  • 为了研究小鼠Suv39h基因组甲基转移酶 (HMTases) 在H3-K9甲基化中的作用,在周心异色素中.
  • 确定Suv39h缺乏对基因组稳定性和哺乳动物发育的体内影响.

主要方法:

  • 在野生型和Suv39h缺乏的小鼠中分析H3-K9甲基化模式.
  • 在Suv39h缺乏的小鼠中评估活力,染色体稳定性,瘤发育和中性染色体配对.

主要成果:

  • Suv39h HMTases 在周心异性染色中建立了一个独特的H3-K9甲基化模式.
  • 缺乏Suv39h的小鼠表现出生命能力受损,染色体不稳定性和瘤易感性增加.
  • 在没有Suv39h的情况下,在雄性半变异过程中观察到扰乱的染色体相互作用.

结论:

  • 围心H3-K9甲基化对于维持体内基因组稳定性至关重要.
  • Suv39h HMTases是哺乳动物发育和基因组完整性的关键表观遗传调节者.