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Updated: May 12, 2026

Detection and Analysis of DNA Damage in Mouse Skeletal Muscle In Situ Using the TUNEL Method
09:54

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Published on: December 16, 2014

瘤坏死因子-α诱导的心力衰竭中的线粒体异常与受损的DNA修复活动有关

Y Y Li1, D Chen, S C Watkins

  • 1Cardiovascular Institute, Center for Biological Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Circulation
|November 14, 2001
PubMed
概括

线粒体DNA修复活性降低导致过度表达TNF-alpha的小鼠心力衰竭. 这表明TNF-alpha可能通过线粒体功能障碍和DNA突变调解心脏损伤.

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