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相关概念视频

Structures of Solids02:22

Structures of Solids

Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
Fischer Projections02:18

Fischer Projections

Learning to draw Fischer projections of molecules and understanding their relevance plays a crucial role in the visual depiction of organic molecules. A Fischer projection is a two-dimensional projection on a planar surface to simplify the three-dimensional wedge–dash representation of molecules. This is especially helpful in the case of molecules with multiple chiral centers that can be difficult to draw. Here, all the bonds of interest are represented as horizontal or vertical lines. While...
Interpreting ¹H NMR Signal Splitting: The (n + 1) Rule01:10

Interpreting ¹H NMR Signal Splitting: The (n + 1) Rule

In the AX proton spin system, proton A can sense the two spin states of a coupled proton X, resulting in a doublet NMR signal with two peaks of equal (1:1) intensity. When proton A is coupled to two equivalent protons (AX2 spin system), the spin states of each X can be aligned with or against the external field, creating three possible scenarios. This results in a 1:2:1  triplet signal, where the central peak corresponds to the chemical shift of A and is twice as large or intense as the others.
Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...

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Rate and factors associated with surgical site infection following aseptic revision fixation of orthopaedic trauma injuries.

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie·2023
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A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B.

Scientific reports·2018
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In vivo effects of two novel ALN-EP4a conjugate drugs on bone in the ovariectomized rat model for reversing postmenopausal bone loss.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2015
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Correction. Biomimetic Models for Cysteine Proteases. 3. Acylation of Imidazolium-Thiolate Zwitterions by p-Nitrophenylacetates as a Model for the Acylation Step and Demonstration of Intramolecular General-Base-Catalyzed Delivery of H(2)O by Imidazole to Thiol Esters as a Model for the Deacylation Step.

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相关实验视频

Updated: Jul 6, 2026

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
09:53

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

Published on: February 6, 2017

立体选择性 (+/-) - 提洛辛A1beta的总合成.

Y Génisson1, P C Tyler, R G Ball

  • 1Merck Frosst Centre for Therapeutic Research, P.O. Box 1005, Pointe Claire-Dorval, Québec, Canada H9R 4P8.

Journal of the American Chemical Society
|November 15, 2001
PubMed
概括

研究人员成功合成了复杂的天然产品氨酸A1beta的总合成. 这种立体特异性合成利用了一种新胺甲基反应和随后的同质化步骤.

科学领域:

  • 有机化学 有机化学
  • 自然产品的合成自然产品的合成

背景情况:

  • 泰洛辛A1beta是一种复杂的天然产品,具有潜在的生物活性.
  • 有效的合成途径对于研究和利用这些化合物至关重要.

研究的目的:

  • 为了实现 (+/-) - 提洛辛A1beta.beta的第一个立体特异性总合成.
  • 开发一种使用关键化学转换的新型合成策略.

主要方法:

  • 合成开始于乙烯5-甲基-2,4-二氧-3,6-二甲基酸盐 (8).
  • 一个关键的步骤涉及循环二烯与低温胺甲基中间体的反应.
  • 通过使用受保护的进行了认证,随后进行了脱保护.

主要成果:

  • 成功完成了 (+/-) - 硫素A1beta的立体特异性总合成.
  • 合成证明了开发的胺甲基方法的实用性.
  • 最终产品是在经过一系列精心控制的反应和脱保护步骤后获得的.

结论:

  • 开发的合成途径提供了 thielocin A1beta.的获取途径.
  • 这项工作扩大了用于天然产品化学的合成工具箱.

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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

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The Development and Application of Biophysical Assays for Evaluating Ternary Complex Formation Induced by Proteolysis Targeting Chimeras (PROTACS)
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Last Updated: Jul 6, 2026

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
09:53

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

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The Development and Application of Biophysical Assays for Evaluating Ternary Complex Formation Induced by Proteolysis Targeting Chimeras (PROTACS)
07:22

The Development and Application of Biophysical Assays for Evaluating Ternary Complex Formation Induced by Proteolysis Targeting Chimeras (PROTACS)

Published on: January 12, 2024

  • 该方法可能适用于合成相关化合物.