对库马林抗凝药物的研究. 在没有加重剂量的情况下开始华法林治疗
1Department of Medicine, Santa Clara Valley Medical Center, Institute for Medical Research of Santa Clara County, San Jose.
Circulation
|July 1, 1968
概括
华法林加重剂量可以避免抗凝药治疗. 每日华法林剂量达到治疗范围,降低出血风险,特别是在敏感患者中.
科学领域:
- 药理学 药理学 是一个学科.
- 临床医学 临床医学
- 血栓形成的研究研究
背景情况:
- 华法林是一种常见的抗凝剂.
- 负载剂量传统上用于快速实现治疗性抗凝剂.
- 加重剂量可能会增加出血风险,特别是在脆弱的患者群体中.
研究的目的:
- 评估替代华法林剂量策略的有效性和安全性.
- 为了比较达到治疗性抗凝剂的时间,加载剂量与每日剂量相比.
- 评估不同华法林疗法对维生素K依赖的凝血因子的影响.
主要方法:
- 30名健康受试者接受了华法林 (1.5毫克/公斤) 的单次充满剂量.
- 在不同的实验中,15名受试者每天服用15毫克或10毫克的剂量.
- 监测出血栓复合物的活性和凝血因子水平 (II,VII,IX,X).
主要成果:
- 治疗范围 (前列红素复合体活性<35%) 达到1.1天的充满剂量,2.7天的15毫克/天,和5.2天的10毫克/天.
- 在所有方法中,当血华法林达到2mg/L时,就能达到治疗水平.
- 在加重剂和15毫克/天疗法之间没有观察到凝血因子降低的显著差异,除了在前48小时的因子VII.
结论:
- 每天服用华法林剂量可以有效诱导治疗性抗凝血作用.
- 避免加重剂量可能会减少出血并发症的风险.
- 这种方法为启动抗凝剂治疗提供了合理的基础,特别是在高风险患者中.
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