在人类慢性心房中,G蛋白结合内向整正K+) 电流 (IK,ACh) 的下调的分子基础:GIRK4 mRNA的下降与IK,ACh的减少以及肌受体介导的动作潜力的缩短有关

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D Dobrev1, E Graf, E Wettwer

  • 1Department of Pharmacology, University of Technology, Dresden, Germany. dobrev@rcs.urz.tu-dresden.de

Circulation
|November 21, 2001
PubMed
概括

人类的慢性心房 (AF) 降低了G蛋白合的向内调整的K+电流 (IK,ACh) 的调节,并提高了向内调整的K+电流 (IK1) 的调节. 在AF中的这种电力改造使肌细胞适应高速率.

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