血管中脑血管收缩:与症状有任何联系吗? 一个跨的多普勒研究
A Lagi1, S Cencetti, V Corsoni
1Department of Internal Medicine, Autonomic Unit, Santa Maria Nuova Hospital, Firenze, Italy. lagi@dada.it
Circulation
|November 28, 2001
概括
在血管之前的大脑血管收缩 (VVS) 不是矛盾的,而是对高通风的生理反应. 在年轻患者中的这一发现表明,VVS并不是主要由异常的大脑血流动力学驱动的.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 生理学 生理学 生理学
背景情况:
- 在血管 (VVS) 中观察到脑血管收缩,由于VVS期间系统血管抵抗降低而显得矛盾.
- 这项研究调查了VVS中大脑血管收缩是否是一个独立的悖论事件,或与症状和发病有关.
研究的目的:
- 要确定VVS中大脑血管收缩是否是一种悖论现象.
- 评估大脑血管收缩,症状和VVS发作之间的关系.
主要方法:
- 七名患有复发性VVS的年轻患者在抬头倾斜时接受了监测.
- 测量包括心率,血压,大脑血流速度 (横多普勒),潮末端PCO2和呼吸系统参数.
- VVS是由头向上倾斜诱导的,并且在昏迷前和昏迷期间记录了生理参数.
主要成果:
- 所有受试者都经历了倾斜诱导的VVS.
- 在VVS之前,潮体积 (深呼吸) 的显著增加发生了>/=160秒.
- 这种高通风导致PCO2降低,脑血流速度降低,脑血管阻力增加.
结论:
- 在VVS之前的大脑血管收缩是由于易感个体的高通风导致的缺口症的生理后果.
- 昏迷发作和脑血管收缩之间的显著延迟表明,VVS主要不是由异常的大脑血液动力学引起的.
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