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Updated: Jul 17, 2026

Dissection and Immunofluorescent Staining of Mushroom Body and Photoreceptor Neurons in Adult Drosophila melanogaster Brains
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德罗斯菲拉脆弱的X相关基因调节MAP1B同类Futsch以控制突触结构和功能

Y Q Zhang1, A M Bailey, H J Matthies

  • 1Department of Biology, University of Utah, Salt Lake City, UT 84112, USA.

Cell
|December 6, 2001
PubMed
概括

在 (dfxr) 中,脆弱的X智障基因 (FMR1) 同类基因调节突触发育. 丢失dfxr会导致突触缺陷,但与Futsch的双重突变者恢复正常功能,揭示了一个调节途径.

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Using Drosophila Larval Neuromuscular Junction and Muscle Cells to Visualize Microtubule Network08:04

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Microtubule Associated Proteins (MAPs)

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Microtubules are hollow cylindrical filaments having a diameter of approximately 25 nm and a length that varies from 200 nm to 25 μm. GTP-bound tubulin subunits form αβ-heterodimers for microtubule assembly. These core building blocks interact longitudinally, polymerizing into protofilaments. The protofilaments then interact with one another through lateral bonding forces to form stable cylindrical microtubules. These cylindrical filaments are dynamic as they undergo repeated assembly and...
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Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.