慢性冠状动脉全封闭的附带功能与区域性心肌功能和封闭的持续时间有关
G S Werner1, M Ferrari, S Betge
1Clinic for Internal Medicine III, Friedrich-Schiller-University Jena, Jena, Germany. gerald.werner@med.uni-jena.de
Circulation
|December 6, 2001
概括
慢性冠状动脉全封闭 (TCO) 的附带功能在正常的心肌功能时更好. 功能受损显示出时间依赖的改善,但由于阻力增加,再通道化减弱了附带流.
科学领域:
- 心血管医学 心血管医学
- 干预心脏病学 干预心脏病学
- 肌心脏生理学 肌心脏生理学
背景情况:
- 附带循环对于在慢性冠状动脉全封闭 (TCO) 中保持心肌活力至关重要.
- 了解心肌功能,闭塞持续时间和附带功能之间的关系对于治疗策略至关重要.
研究的目的:
- 评估心肌功能与慢性冠状动脉全封闭 (TCO) 持续时间之间的相关性.
- 评估重新道化对抵押品功能和阻力的影响.
主要方法:
- 使用冠心内多普勒和压力记录评估50名接受TCO再通道化治疗的患者的附带功能.
- 在皮肤透光冠状动脉血管塑造术 (PTCA) 之前和之后,测量了附带流量指数 (CFI(D),CFI(P)) 和阻力指数 (R(Coll),R(P)).
主要成果:
- 患有normokinesia (正常心肌运动) 的患者的附带和外围抵抗明显低于患有 akinesia (缺乏运动) 的患者.
- 与TCO持续时间≤3个月的阿基尼西亚显示出最高的耐药性;更长的持续时间与正常动力患者具有相似的耐药性.
- 重化显著降低了附带流量指数,增加了附带和外围阻力,对表心附带的减弱较小.
结论:
- 在TCO患者中,附带功能优于具有保留区域心肌功能的TCO患者.
- 在功能受损的患者中,附带改善是时间依赖的.
- 由于阻力增加,重新道化减弱了可招募的附带功能.
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