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Updated: Jul 13, 2026

Orthotopic Aortic Transplantation in Mice for the Study of Vascular Disease
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阿波利波蛋白E对动脉动脉生成的异形特异性影响:在小鼠中进行基因转导研究

H Yoshida1, A H Hasty, A S Major

  • 1Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

Circulation
|December 6, 2001
PubMed
概括

巨细胞衍生的阿波利波蛋白E3 (apoE3) 能防止动脉样硬化. 这项研究表明,apoE3的保护作用依赖于它结合细胞受体的能力,而不仅仅是它的存在.

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...