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在2型,但不包括1型的转基因淘汰后,小鼠的内皮细胞功能障碍,11β-hydroxysteroid脱酶

P W Hadoke1, C Christy, Y V Kotelevtsev

  • 1Endocrinology, Endothelial Cell Biology, and Molecular Physiology groups, University of Edinburgh, Edinburgh, UK. phadoke@srv0.med.ed.ac.uk

Circulation
|December 6, 2001
PubMed
概括

11β-Hydroxysteroid脱酶2型 (11β-HSD2) 缺乏会损害血管内皮功能,导致因北上腺素诱导的收缩和血管扩张受损. 在淘汰赛小鼠中观察到的这种功能障碍可能会导致高血压,并且独立于脏留.

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