冠状动脉旁路手术后抑郁症与12个月后的结果之间的关系:一项前性研究
I Connerney1, P A Shapiro, J S McLaughlin
1Mailman School of Public Health, Columbia University, New York, NY, USA. iconnerney@umm.edu
Lancet (London, England)
|December 6, 2001
概括
抑郁症显著增加了冠状动脉旁路移植 (CABG) 手术后心脏事件的风险. 识别和治疗这些患者的抑郁症对于改善心脏病结果至关重要.
科学领域:
- 心脏病学 心脏病学
- 精神病学是一种精神病学.
- 健康 结果 研究 研究 结果
背景情况:
- 以前关于抑郁症和心脏事件的研究集中在社区队列或心肌梗塞后患者身上.
- 抑郁症对冠状动脉旁路移植 (CABG) 手术后的结果的影响需要进一步调查.
研究的目的:
- 为了评估抑郁症对心脏和非心脏结局的影响,在接受CABG手术的患者中.
主要方法:
- 一项前性研究跟踪了309名患者 (207名男性,102名女性) 在CABG后的一年.
- 在出院前使用诊断面试时间表和贝克抑郁症清单来评估抑郁症.
- 心脏事件包括再次住院治疗心痛或心力衰竭,心肌梗塞,心脏骤停,重复手术和心脏死亡率.
主要成果:
- 在20%的患者中诊断出严重抑郁症.
- 患有抑郁症的患者在12个月内心脏事件的发生率显著增加 (27%vs. 10%) (p<0.0008).
- 在考克斯模型中,抑郁症,低射出率和女性是心脏不良结果的独立预测因素.
结论:
- 抑郁症是CABG手术后心脏事件的重要和独立的风险因素.
- 这些发现凸显了治疗CABG后患者抑郁症的重要性,以减轻心脏风险.
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