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抑制性PAS域蛋白是低氧诱导基因表达的负调节者

Y Makino1, R Cao, K Svensson

  • 1Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institutet, S-171 77 Stockholm, Sweden.

Nature
|December 6, 2001
PubMed
概括

一种新型蛋白质,抑制性PAS (IPAS),可以负面调节缺氧诱导因子 (HIF),控制基因表达. IPAS 抑制瘤生长和血管生成,为缺氧相关疾病提供新的治疗点.

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