由心肺和动脉巴罗反射机制诱导的心脏自主控制的顺序调节
R Furlan1, G Jacob, L Palazzolo
1Medicina Interna II, Ospedale L. Sacco, Dipartimento Scienze Precliniche LITA di Vialba, Università degli Studi di Milano, Italy. Raffaellof@fisiopat.sacco.unimi.it
低强度下体负压 (LBNP) 在发生血液动力学变化之前,非侵入性地增加心脏交感调制,用LF(R-R表示. 这种心率变化的自主转变在模拟低血压期间的巴罗反射调整之前.
科学领域:
- 心血管生理学心血管生理学
- 自主神经系统的调节规则
- 人体生理学 人体生理学
背景情况:
- 非潜在的下体负压 (LBNP) 增加了前臂血管阻力和交感神经活动,而不会改变平均心率.
- 研究了低强度LBNP期间心率变化的自主调制是否会影响平均心率.
研究的目的:
- 测试假设,在低强度LBNP期间,心跳自主调制反射变化.
- 评估LBNP期间心率变化和巴罗反射灵敏度的变化.
主要方法:
- 十名健康志愿者接受了高达-40毫米升的LBNP.
- 持续监测心电图,血压,呼吸,中央静脉压 (CVP) 和血中类甲醇胺.
- 对心血管变异性的光谱和跨光谱分析以及巴罗受体敏感性评估.
主要成果:
- 随着LBNP的逐渐降低,CVP,R-R间隔和静脉压逐渐降低.
- 通过LF (R-R) 评估的心交感调制,在-15 mm Hg LBNP时显著增加.
- 血北上腺素增加,在较高的LBNP水平下,巴罗反射灵敏度下降.
结论:
- 非潜在的LBNP诱导心交感调节的反射增加.
- 这种同情调制,用LF(R-R表示,发生在血液动力学和动脉巴罗反射控制的变化之前.
- 这些发现突出了对模拟低血压症的早期自主调整.
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