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疑似食物过敏儿童的假负食物挑战
1Paediatric Department, University of Parma, 43100, Parma, Italy. Carlo.Caffarelli@unipr.it
Lancet (London, England)
|December 14, 2001
概括
一小部分儿童最初在口服食品挑战期间耐受食物,在家中发展了立即的过敏反应. 这表明,开放式食品挑战对于确认食物过敏和减少虚假负面是有价值的.
科学领域:
- 儿科过敏和免疫学
- 临床营养学 临床营养学
- 诊断免疫学 诊断免疫学
背景情况:
- 准确诊断食物过敏对于有效管理至关重要.
- 口服食物挑战 (OFC) 是一种标准的诊断工具.
- 立即发生的反应是IgE介导的食物过敏的特征.
研究的目的:
- 评估在负面的OFC之后,开放式食品挑战的实用性.
- 识别初始OFC的潜在假负结果.
- 为了提高儿童食物过敏诊断的准确性.
主要方法:
- 370个口服食物挑战对242名儿童进行了管理.
- 在OFC期间耐受食物的儿童第二天在家中接受了开放式食物挑战.
- 评估了皮肤刺伤测试和特定IgE抗体水平.
- 随后的双盲,安慰剂控制的食物挑战 (DBPCFC) 用于确认.
主要成果:
- 在OFC期间容忍食物的193名儿童中,有5名儿童 (3%) 在家中公开挑战时立即表现出症状.
- 所有确诊过敏的儿童都有阳性皮肤刺伤测试.
- 除了一个孩子外,所有孩子都有可检测的针对致病食物的特定IgE抗体.
结论:
- 在负面的OFC后一天进行的开放式食品挑战可以显示立即的反应.
- 这种方法有助于识别错误负的OFC结果.
- 观察到的开放养增加了对食物过敏诊断的可靠性.
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