c-Myc通过控制细胞数量而不是细胞大小来调节哺乳动物的体型
A Trumpp1, Y Refaeli, T Oskarsson
1Swiss Institute for Experimental Cancer Research (ISREC), Ch. des Boveresses 155, CH-1066 Epalinges, Switzerland. Andreas.Trumpp@isrec.unil.ch
Nature
|December 14, 2001
概括
原型瘤基因c-Myc调节哺乳动物的细胞分裂和器官大小. 在小鼠中降低c-Myc水平导致器官缺血,证明其在发育中的关键作用.
科学领域:
- 分子生物学分子生物学
- 发展生物学 发展生物学
- 在瘤学瘤学.
背景情况:
- 原型瘤基因c-Myc在人类瘤中经常过度表达.
- 在正常生理学和瘤发生过程中c-Myc的确切作用尚不清楚.
- 了解c-Myc的功能对于癌症研究和发育生物学至关重要.
研究的目的:
- 研究c-Myc在哺乳动物发育和生理学中的功能.
- 阐明c-Myc在细胞循环调节和器官大小确定中的作用.
- 为了比较c-Myc在哺乳动物和昆虫中的功能.
主要方法:
- 产生一种具有逐渐减少c-myc表达的小鼠等位基序列.
- 对纤维细胞增殖和细胞循环退出的分析,以应对c-Myc损失.
- 在体内评估不同c-Myc水平的小鼠的器官大小和体重.
- 在小鼠和Drosophila模型中对c-myc功能的比较.
主要成果:
- 纤维细胞中c-Myc功能的丧失导致细胞周期的结束.
- c-Myc活动对于T细胞重新进入细胞周期至关重要.
- 在小鼠中降低c-Myc水平导致多器官低成形和体重减少.
- 哺乳动物和昆虫的c-myc同类在纤维细胞中表现出类似的生物活动.
结论:
- c-Myc在细胞分裂的决定中起到关键的调解作用,影响器官和身体大小.
- 哺乳动物和昆虫可以利用不同的机制来控制身体大小.
- 这项研究为c-Myc在调节细胞增殖和生物体发育方面的基本作用提供了新的见解.
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