细菌基基因组是光色的基因酶,使用色基因组的色基因组
S H Bhoo1, S J Davis, J Walker
1Cellular and Molecular Biology Program, Department of Horticulture, University of Wisconsin-Madison, 1575 Linden Drive, Madison, Wisconsin 53706, USA.
Nature
|December 14, 2001
概括
细菌染色体 (BphP) 是广泛存在的细菌光传感器,与植物染色体不同. 这些BPHP使用比利弗丁,并且与histidine激酶同源,这表明它们是古代光受体的祖先.
科学领域:
- 微生物学 微生物学
- 生物化学 生物化学
- 摄影生物学 摄影生物学
背景情况:
- 植物染色体是植物中关键的红色/远红色光传感器.
- 以前人们认为植物染色体只存在于光合作用生物体中.
- 最近的发现确定了异构型细菌中类似植物色素的蛋白质.
研究的目的:
- 研究细菌中植物色样蛋白质的性质和流行情况.
- 了解这些细菌光受体的生物化学特性和进化起源.
主要方法:
- 同性学在细菌基因组中寻求识别类似植物染色体的蛋白质.
- 蛋白质-染色体相互作用的生物化学分析.
- 基因表达研究在体内检查BphP组件.
主要成果:
- 在多种细菌中鉴定出一种广泛的细菌基染色体 (BphPs) 家族.
- BphPs与双组分传感器胺激酶是同类的.
- BphPs使用比利弗丁作为染色体,与植物植物染色体不同,植物染色体使用植物染色素.
- 在某些情况下,特定的血氧酶用于胆固醇合成与BphP基因共定位.
- 在体内可以通过BphP阿波蛋白,血源和相关的血氧酶的共同表达来实现Holo-BphP组合.
结论:
- 细菌ophytochromes代表一个独特和古老的类型的光受体.
- 它们在细菌中的广泛分布和更简单的组装机制表明BphPs是植物植物染色体的进化前体.
- BphPs作为光调节的光色基因酶起作用,将光感应与细菌中的细胞信号连接起来.
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