低肝脂酶活性是冠状动脉疾病的新型风险因素
K A Dugi1, K Brandauer, N Schmidt
1Department of Internal Medicine I, Internal Medicine III, University of Heidelberg, Heidelberg, Germany. klaus_dugi@med.uni-heidelberg.de
Circulation
|December 19, 2001
概括
低肝脂酶 (HL) 活性与冠状动脉疾病 (CAD) 有关. 这一发现表明HL可能有助于CAD风险评估,并可能成为新治疗的目标.
科学领域:
- 脂质代谢 脂质代谢是什么
- 心血管疾病研究研究
- 生物化学 生物化学
背景情况:
- 肝脂酶 (HL) 在脂质代谢中起着关键作用.
- HL活动与冠状动脉疾病 (CAD) 之间的关联仍在争论中.
研究的目的:
- 调查肝脂酶活性与冠状动脉疾病程度之间的关系.
- 探索HL活动作为CAD风险生物标志物的潜力.
主要方法:
- 在200名接受冠状动脉血管造影的男性中测量了后血HL活性.
- 使用经过验证的范围得分评估CAD范围.
- 进行多变体分析并检查HL促进体 (-514 T等位基因) 的遗传变异.
主要成果:
- 在HL活动和CAD程度之间发现了显著的反相关性 (r=-0.19,P<0.01).
- 与对照组相比,患有CAD的患者的HL活性较低 (286+/-106相比338+/-108nmol.mL(-1).min(-1),P<0.01).
- HL促进物-514 T等位基因与HL活性降低和CAD程度增加有关.
结论:
- 低肝脂酶活性与冠状动脉疾病独立相关.
- HL活动可以作为估计CAD风险的有价值工具.
- 在CAD管理中,HL可能是未来药理干预的潜在目标.
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