甲状腺功能增强症及其纠正对人类血管反应性的影响
R Napoli1, B Biondi, V Guardasole
1Department of Internal Medicine and Cardiovascular Sciences, University Federico II School of Medicine, Naples, Italy.
Circulation
|December 19, 2001
概括
甲状腺激素 (TH) 显著影响人类的血管反应. 甲状腺功能障碍导致血管扩张和改变反应,治疗后正常化,表明内皮是TH的关键目标.
科学领域:
- 心血管生理学心血管生理学
- 内分泌学 在内分泌学.
- 血管生物学 血管生物学
背景情况:
- 甲状腺激素 (TH) 影响心血管系统,但其在人类血管反应中的作用尚不清楚.
- 甲状腺功能障碍与心血管变化有关,但对血管功能的具体影响仍有待阐明.
研究的目的:
- 研究甲状腺激素对人类血管反应的调节.
- 为了确定甲状腺功能障碍是否会改变前臂对血管活性剂的血流反应.
- 评估恢复性甲状腺功能对血管功能的影响.
主要方法:
- 研究了8名甲状腺过高患者 (H),治疗后6个月 (EU) 和13名健康对照 (C).
- 测量前臂血流 (FBF) 使用张力计囊造影.
- 用于支臂内注射的乙胆,酸 (SNP),上腺素和L-NMMA (氧化合成酶抑制剂).
主要成果:
- 与对照组相比,甲状腺功能高的患者的基础FBF显著高于对照组,并在治疗后正常化.
- 乙胆诱导的血管扩张在甲状腺功能过高患者中被夸大.
- 在甲状腺功能高的患者中,上腺素诱导的血管收缩被强化.
- 在甲状腺功能高的人群中,L-NMMA 降低了更多的FBF,这表明氧化的产生增加了.
结论:
- 甲状腺功能障碍症引起明显的基础血管扩张,主要是由于内皮氧化 (NO) 的过度产生.
- 由于内皮敏感性增加,甲状腺功能过强症中血管反应性得到增强.
- 在甲状腺功能过高的状态下,对诺拉上腺素的血管收缩反应被强化.
- 顺甲状腺症的医疗恢复可以纠正这些血管异常,确认内皮是甲状腺激素的目标.
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