爱斯坦-巴尔病毒抗体和多发性硬化症风险:一项前性研究
A Ascherio1, K L Munger, E T Lennette
1Harvard School of Public Health, Nutrition Department, 665 Huntington Ave, Boston, MA 02115, USA. Alberto.Ascherio@channing.harvard.edu
JAMA
|January 5, 2002
概括
在患上多发性硬化症 (MS) 之前,在女性中发现对爱斯坦-巴尔病毒 (EBV) 蛋白质,特别是EBNA-2的抗体升高. 这些发现支持EBV在MS病因学中的作用.
科学领域:
- 神经免疫学 神经免疫学
- 病毒免疫学 病毒免疫学
- 流行病学 流行病学
背景情况:
- 流行病学研究表明,爱斯坦-巴尔病毒 (EBV) 感染与多发性硬化症 (MS) 风险增加之间存在联系.
- 需要进一步调查,以了解EBV抗体标位和MS发病之间的时间关系.
研究的目的:
- 为了调查血清抗体位对各种爱斯坦-巴尔病毒 (EBV) 抗原的升高是否先于多发性硬化症 (MS) 的诊断.
- 为了检查抗体标位与细胞巨血病毒 (CMV) 和MS发生之间的关联.
主要方法:
- 一项前性,嵌套的病例控制研究,涉及来自护士健康研究和护士健康研究II的62,439名女性.
- 分析包括144名被诊断患有多发性硬化症的妇女和288名年龄相匹配的健康对照,在疾病发病前采集的血液样本.
- 测量了对EBV和CMV抗原的血清抗体标位,并在病例和对照之间进行了比较.
主要成果:
- 与对照人群相比,患MS的女性对EBV抗原的血清抗体标位显著更高,包括EBNA-1,EBNA-2和EA-D.
- 对EBNA-2的抗体显示出与MS风险的最强相关性,标位的4倍差异与3.9倍的风险增加相关.
- 在细胞巨血病毒 (CMV) 抗体标位和MS发展之间没有发现显著的关联.
结论:
- 这些发现提供了支持爱斯坦-巴尔病毒 (EBV) 在多发性硬化症 (MS) 病因学中的作用的证据.
- 在MS发作之前,EBV抗体标位升高表明存在潜在的因果关系或显著的促成因素.
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