持续的人类乳头瘤病毒感染作为宫内皮质瘤的预测因素
N F Schlecht1, S Kulaga, J Robitaille
1Department of Oncology, McGill University, 546 Pine Ave W, Montreal, Quebec, Canada H2W1S6. eduardo.franco@mcgill.ca
JAMA
|January 5, 2002
概括
持续的人类乳头瘤病毒 (HPV) 感染,特别是 HPV 型 16 或 18 的感染,显著增加了发展状内皮病变 (SILs) 的风险,这是宫癌的前体.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- 人类乳头瘤病毒 (HPV) 感染是导致子宫癌的主要原因.
- 大多数将HPV与子宫癌联系在一起的证据来自回顾性研究.
- 关于累积或持续的HPV暴露动态的数据有限.
研究的目的:
- 评估持续性HPV感染与子宫瘤发病风险之间的关联.
- 评估特定瘤性HPV类型对病变发展的影响.
主要方法:
- 从1993年到2000年,在巴西圣保罗进行了一项纵向研究.
- 1611名没有初始细胞学病变的妇女接受了重复的HPV检测和细胞学.
- 宫样本最初每4个月进行一次HPV和Papanicolaou细胞学分析,然后每年两次.
主要成果:
- 状内皮病变 (SILs) 的发病率在患有持续性HPV感染的女性中显著更高.
- 患有持续性HPV类型16或18感染的女性显示SILs的风险大幅增加.
- 发生性SIL的相对风险 (RR) 在持续的瘤性HPV感染中为10.19,在高度SIL中为11.67.
结论:
- 持续性HPV感染和SIL的发病率之间存在很强的相关性.
- 16型和18型HPV感染显示出特别高的子宫瘤发病风险.
- 纵向数据证实了持续性HPV在宫癌发展中的关键作用.
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