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Human Serum Anti-aquaporin-4 Immunoglobulin G Detection by Cell-based Assay
Published on: April 5, 2019
诺和虚假阳性尿液查阿片类药物通过免疫测试技术
L R Baden1, G Horowitz, H Jacoby
1Division of Infectious Diseases, Brigham and Women's Hospital, 15 Francis St, PBB-A400, Boston, MA 02115, USA. lbaden@partners.org
JAMA
|January 5, 2002
概括
昆类抗菌素可以在阿片类查试验中引起假阳性结果. 这种与勒沃素等常见抗生素观察到的交叉反应性,需要仔细解释药物测试结果.
科学领域:
- 临床化学 临床化学
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
背景情况:
- 每年都会进行数以百万计的药物滥用测试.
- 由于药物交叉反应,药物测试试验的假阳性结果可能会出现,导致不准确的结论.
研究的目的:
- 在常见的阿片类查试验中评估类抗菌素的交叉反应性.
- 为了评估这种诺-阿片酸试验交叉反应性的体内影响.
主要方法:
- 测试了13种诺与5种商业片查试验进行了对比.
- 在接受levofloxacin或ofloxacin的6名健康志愿者中证实了交叉反应性.
主要成果:
- 在至少一项测试中,九种类素的测试结果超过了阳性值.
- 四种测试系统至少为一种诺产生了假阳性结果.
- 利沃弗洛克萨,奥洛克萨和佩弗洛克萨最有可能导致虚假阳性阿片类药物结果.
结论:
- 对诺隆与阿片类药物免疫试验的交叉反应性的注意力增加至关重要.
- 为了尽量减少无效测试解释的可能性,需要解决这个现象.
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