绝经后妇女的维生素A摄入量和部骨折
Diane Feskanich1, Vishwa Singh, Walter C Willett
1Channing Laboratory, 181 Longwood Ave, Boston, MA 02115. diane.feskanich@channing.harvard.edu
JAMA
|January 12, 2002
概括
高摄入维生素A,特别是视网醇,与绝经后妇女部骨折风险增加有关. 这表明需要重新评估食品和补充剂中维生素A的建议每日摄入量.
科学领域:
- 营养流行病学 营养流行病学
- 骨健康研究 骨健康研究
- 公共卫生 营养 公共卫生 营养
背景情况:
- 众所周知,高维生素A摄入量会对动物的骨重塑产生不利影响.
- 有关长期高维生素A消费对人类骨折风险的潜在贡献存在担忧.
研究的目的:
- 调查从食物和补充剂中摄取高维生素A与绝经后妇女关节骨折风险之间的联系.
主要方法:
- 一项前性队列研究涉及来自护士健康研究的72,337名绝经后妇女,随访时间为18年.
- 维生素A摄入量 (总量,视网醇,β-胡卜素) 和补充剂的使用在基线时被评估并更新.
- 与维生素A摄入量五分之一相比,分析了发生关节骨折的情况.
主要成果:
- 总维生素A摄入量最高五分之一的女性 (≥3000微克RE/天) 显示关节骨折的风险显著增加 (RR, 1.48).
- 这种增加的风险主要与网醇摄入量有关 (RR,1.89对于≥2000μg/天而不是<500μg/天),而不是β-胡卜素.
- 从食物中摄入高水平的视网醇与骨折风险有显著的关联,特别是在不服用补充剂的女性中.
结论:
- 长期通过饮食摄入大量的视网醇可能会增加女性骨质疏松性关节骨折的风险.
- 强化食品和维生素补充剂中的当前视网醇水平需要重新评估,以减轻潜在的骨风险.
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