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Updated: Jun 25, 2026

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
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A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses

Published on: August 31, 2014

复制无能力的腺病毒疫苗载体引起有效的抗免疫缺陷病毒免疫力

John W Shiver1, Tong-Ming Fu, Ling Chen

  • 1Merck Research Laboratories, West Point, Pennsylvania 19486, USA.

Nature
|January 18, 2002
PubMed
概括

复制无能力的5型腺病毒 (Ad5) 载体在子中有效诱导细胞免疫反应对抗猿类免疫缺陷病毒 (SIV). 单独或作为助推剂的Ad5载体在挑战后显示出显著的病毒衰减,这表明对HIV-1疫苗开发有希望.

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