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Updated: Mar 1, 2026

Promotion of Survival and Differentiation of Neural Stem Cells with Fibrin and Growth Factor Cocktails after Severe Spinal Cord Injury
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在没有神经生长因子的逆行运输的情况下,逆行支持神经细胞生存

Bronwyn L MacInnis1, Robert B Campenot

  • 1Department of Cell Biology, 6-14 Medical Sciences Building, University of Alberta, Edmonton, Alberta, Canada, T6G 2H7.

Science (New York, N.Y.)
|January 19, 2002
PubMed
概括

神经生长因子 (NGF) 珠通过在没有显著 NGF 运输的情况下向细胞体发出信号来促进神经元的生存. 这挑战了长期以来的信念,即NGF本身必须到达细胞体以确保神经元的生存.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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