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通过基因表达造型鉴定,识别高风险乳腺癌患者

André Ahr, Thomas Karn, Christine Solbach

    Lancet (London, England)
    |January 26, 2002
    PubMed
    概括

    分子分析确定了一种易转移的高风险乳腺癌亚型 (A类). 即使是这个组的节点阴性患者也显示出远程的疾病进展,表明需要量身定制的疗法.

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    Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...