通过激素放松素激素激活孤儿受体
Sheau Yu Hsu1, Koji Nakabayashi, Shinya Nishi
1Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
概括
研究人员确定了放松素受体LGR7和LGR8,这对怀孕至关重要. 阻止LGR7在小鼠中延迟分娩,揭示了生殖和其他功能的新治疗点.
科学领域:
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
- 生殖生物学 生殖生物学
背景情况:
- 放松素是一种关键的怀孕激素,调节组织生长和重塑.
- 尽管有广泛的结合部位,但中介于放松素作用的特定受体仍然未被确定.
研究的目的:
- 为了确定负责调解放松素的生物作用的孤儿受体.
- 阐明通过其识别的受体通过放松素激活的信号通路.
主要方法:
- 使用孤儿G蛋白结合受体LGR7和LGR8.
- 研究了放松素对腺3',5'-单酸盐 (cAMP) 水平的影响.
- 给孕小鼠使用可溶性LGR7联体结合区域.
主要成果:
- 证实LGR7和LGR8是功能性放松素受体.
- 放松素信号通过一种依赖于cAMP的通路运行,与胰岛素/IGF通路不同.
- 在小鼠中抑制LGR7导致分娩延迟.
结论:
- 确定LGR7和LGR8是激素放松素的主要受体.
- 这一发现为Relaxin独特的cAMP介导信号通路提供了洞察力.
- 这些受体的广泛分布表明它们在生殖,神经,脏和心血管系统中扮演着不同的角色.
相关概念视频
Receptor Downregulation in MVBs
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR activation may...
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR activation may...
GPCR Desensitization
G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...


