吸入的颗粒进入人类的血液循环
A Nemmar1, P H M Hoet, B Vanquickenborne
1Laboratory of Pneumology (Lung Toxicology, Katholieke Universiteit Leuven, Leuven, Belgium.
Circulation
|January 30, 2002
概括
吸入的超细颗粒很快进入血液,这可能解释了空气污染.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 心血管研究研究心血管研究
背景情况:
- 空气中的颗粒物污染与心血管疾病有关.
- 这些影响背后的机制仍然不清楚.
研究的目的:
- 为了研究吸入的超细颗粒的全身循环.
- 为了确定粒子转移的速度和程度.
主要方法:
- 健康的志愿者吸入了标有Technetium (99m) 的超细碳颗粒 (<100 nm).
- 血液和身体分布中的放射性被测量使用马相机.
- 使用薄层染色学分析的血液样本.
主要成果:
- 在吸入后1分钟内检测到血液中的放射性.
- 血中放射性活动的峰值在10到20分钟之间观察到,持续60分钟.
- 在血液中检测到颗粒结合和氧化技术;肝脏显示出显著的放射性.
结论:
- 吸入的超细碳颗粒迅速进入全身循环.
- 这种快速转移可能解释了空气污染对肺外的影响.
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