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基因表达造型预测乳腺癌的临床结果

Laura J van 't Veer1, Hongyue Dai, Marc J van de Vijver

  • 1Division of Diagnostic Oncology, The Netherlands Cancer Institute, 121 Plesmanlaan, 1066 CX Amsterdam, The Netherlands.

Nature
|February 2, 2002
PubMed
概括

研究人员确定了一种基因表达特征,以预测乳腺癌转移. 这种不良预后的特征有助于识别那些可能受益于特定辅助疗法的患者,从而改善治疗策略.

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...