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放射性"冷端"支架植入后的血管学随访:一个多中心试验

A J Wardeh¹, R Albiero, I P Kay

¹Thoraxcenter Rotterdam, Daniel den Hoed Cancer Center, University Hospital Rotterdam, Rotterdam, The Netherlands.

|February 6, 2002

概括

设计用于防止支架边缘的复缩的Cold Ends支架没有解决这个问题. 静止病转移到非放射性末端,最严重的病例发生在过渡区.

科学领域:

心血管医学心血管医学
生物医学工程生物医学工程
干预心脏病学干预心脏病学

背景情况:

放射性支架与显著的边缘复缩 (>40%) 相关,原因是新极端增生和负重塑.
边缘复缩仍然是冠状动脉干预的挑战,影响长期结果.

研究的目的:

评估新型"Cold Ends"支架在解决边缘复缩症方面的疗效.
为了确定防止受伤四肢的重塑是否可以减少新极度增生症.

主要方法:

进行了一项涉及43名新生冠状动脉疾病患者的试验.
植入了25毫米"冷端"支架 (15毫米放射性中心,5毫米非放射性末端),具有3-12微Ci活性.
植入后评估了支架凝血和复原率.

主要成果:

在研究人群中观察到22%的缩率.
静止病从传统放射性支架的边缘转移到"冷端"支架的非放射性末端.
最严重的复原发生在放射性-非放射性过渡区,即剂量下降的区域.

结论:

"冷端"支架未能解决边缘复缩的问题.
设计并没有防止复原,而是将其转移到非放射性部分和过渡区.

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