在检测透析功能障碍时B-尿素的实用性:与多普勒速度记录的比较
Emily Lubien1, Anthony DeMaria, Padma Krishnaswamy
1Division of Cardiology, Department of Medicine, Veteran's Affairs Medical Center, and University of California, San Diego, USA.
Circulation
|February 6, 2002
概括
升高的B-性尿素 (BNP) 水平可以准确地检测正常缩功能的患者的舒张功能障碍,补充心声扫描的发现,以便更可靠的诊断.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 诊断成像 诊断成像 诊断成像
背景情况:
- 多普勒心声学在充分评估腹功能障碍方面存在局限性.
- 乙-尿素 (BNP) 可能反映心室压力,这表明它在诊断腹异常方面的潜在作用.
研究的目的:
- 调查B-尿素 (BNP) 水平是否可以预测正常缩功能患者的透析异常.
主要方法:
- 294名患有正常缩功能的患者接受了心声回声扫描.
- 评估了左心室 (LV) 扩张功能,并对患者进行了分类.
- 在评估过程中,心脏病学家对B-性尿素 (BNP) 水平失明.
主要成果:
- 腹功能异常的患者 (n=119) 的平均BNP水平 (286 pg/mL) 比正常功能 (n=175,33 pg/mL) 的患者高得多.
- 限制性填充模式显示了最高的BNP水平 (408 pg/mL).
- 62 pg/mL的BNP截止值在检测腹功能障碍时显示了84%的准确性.
结论:
- 快速的B-尿素 (BNP) 测试可靠地检测透支异常.
- 升高的BNP水平,结合心声学,可以加强在患有保存缩功能的患者中扩张性功能障碍的诊断.
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