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婴儿和儿童的死后组织狄戈辛度

P W Kim, R W Krasula, L F Soyka

|December 1, 1975

概括

与较大的儿童相比,早产婴儿和新生儿在心脏组织中表现出显著更高的狄戈辛度. 这些发现表明当前婴儿迪戈辛剂量可能过高,需要仔细考虑.

科学领域:

药理学药理学是指药理学的学科.
儿科医学儿科医学
毒理学毒理学毒理学

背景情况:

迪戈辛是一种用于治疗心力衰竭和心律失常的心脏糖化物.
婴儿的迪戈辛的药理动力学和组织分布与成人不同.
尸体解剖数据为各种年龄段的药物分配提供了宝贵的见解.

研究的目的:

为了确定早产婴儿,满期婴儿和年龄较大的儿童组织中的狄戈辛度.
为了比较不同儿科年龄组的迪戈辛组织分布.
评估观察到的狄戈辛度对婴儿推剂量的潜在影响.

主要方法:

放射性免疫检测用于量化狄戈辛度.
分析的组织包括右心室和左心室以及脏.
从早产婴儿,满期婴儿和老年儿童群体中已故的个体获得样本.

主要成果:

婴儿 (早产和满期) 在心室组织中表现出显著更高的狄戈辛度 (大约为1. 190 ng/g) 与年龄较大的儿童相比 (约. 70 ng/g) 的情况.
在早产婴儿中,脏迪戈辛度较低,可能与未成熟的功能有关.
在婴儿和老年儿童之间观察到狄戈辛分布的显著差异.

结论:

婴儿心肌胆固醇狄戈辛度大大高于年龄较大的儿童.
在早产婴儿中,脏度较低可能反映出分泌能力降低.
婴儿心脏迪戈辛的高水平表明,标准剂量方案可能过高.

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