安慰剂和阿片类止痛药 - - 绘制共享的神经网络的图像
Predrag Petrovic1, Eija Kalso, Karl Magnus Petersson
1Cognitive Neurophysiology Research Group, Department of Clinical Neuroscience, Karolinska Institute, Stockholm 171 76, Sweden., Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Finland.
概括
安慰剂和阿片类止痛药共享类似的大脑机制. 两者都激活面前环状皮质 (rACC) 并涉及大脑干连接,表明疼痛调节的共同神经通路.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 心理学 心理学 心理学
背景情况:
- 据认为,安慰剂镇痛涉及认知网络和内源性阿片类药物.
- 面前环状皮质 (rACC) 和脑干是阿片类药物止痛的关键.
研究的目的:
- 为了研究背后的神经机制安慰剂止痛.
- 为了确定安慰剂止痛药是否与阿片类止痛药共享神经通路.
主要方法:
- 用正子发射断层扫描 (PET) 来测量大脑活动.
- 在阿片类止痛药,安慰剂止痛药和仅疼痛条件下对脑活动进行了比较.
主要成果:
- 无论是阿片类药物和安慰剂止痛药在rACC中都显示出增加的活性.
- 在阿片类药物和安慰剂止痛治疗期间观察到rACC和脑干活动之间的共变,但不是仅在疼痛期间.
结论:
- 安慰剂和阿片类止痛药涉及相关的神经机制.
- rACC和脑干在安慰剂和阿片类药物疼痛缓解中都起作用.
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