细胞膜转脂肪酸和初级心脏骤停的风险
Rozenn N Lemaitre1, Irena B King, Trivellore E Raghunathan
1Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle 98101, USA. rozenl@u.washington.edu
Circulation
|February 13, 2002
概括
饮食中摄入的反式脂肪酸与初级心脏骤停的风险增加有关. 具体来说,氨基酸的转变异构体与更高的心脏骤停风险有显著的关联.
科学领域:
- 心血管流行病学心血管流行病学
- 营养科学 营养科学
- 生物标志物研究 生物标志物研究
背景情况:
- 转脂肪酸 (TFA) 消费与危及生命的心律失常,包括初级心脏骤停之间的关联在很大程度上是未知的.
- 了解心脏骤停的饮食风险因素对于公共卫生倡议至关重要.
研究的目的:
- 通过红细胞膜生物标志物测量TFA摄入量与初级心脏骤停风险之间的关系.
- 为了区分与特定的反式脂肪酸异构体相关的风险.
主要方法:
- 基于人口的病例控制研究进行了179例医院外心脏骤停病例和285个年龄和性别匹配的对照.
- 通过在心脏骤停或采访时采集的血液样本来评估反式脂肪酸水平.
- 参与者没有先前确诊的心脏病.
主要成果:
- 红细胞膜中较高的TFA总水平与初级心脏骤停风险的适度增加有关 (OR,1.5;95% CI,1.02.1).
- 油酸的转变异构体与心脏骤停风险没有显著的关联 (OR,0.8;95% CI,0.51.2).
- 临 linoleic 酸的转变异构体水平升高与初级心脏骤停风险增加三倍密切相关 (OR,3.1;95% CI,1.75.4).
结论:
- 饮食中摄入的总转化脂肪酸与初级心脏骤停风险的适度增加有关.
- 具体来说,氨基酸的转变异构体与心脏骤停风险的更大增加有显著的关联.
- 需要进一步的研究来证实这些发现,并区分特定的反式脂肪酸异构体.
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